Get Science Right in Canada

Get Science Right

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John Mattick on the Importance of Non-coding RNA

John Mattick is a Professor and research scientist at the Garvan Institute of Medical Research at the University of New South Wales (Australia). He received an award from the Human Genome Organization for ....

The Award Reviewing Committee commented that Professor Mattick’s “work on long non-coding RNA has dramatically changed our concept of 95% of our genome”, and that he has been a “true visionary in his field; he has demonstrated an extraordinary degree of perseverance and ingenuity in gradually proving his hypothesis over the course of 18 years.”

Read more »

The Best Enzyme

Theme

Better BiochemistryWhile I was collecting posts on biochemistry, I came across one that I wrote almost five years ago. It was about a new record for catalytic proficiency. As you know, enzymes speed up reactions that occur naturally and spontaneously. The difference between the spontaneous rate and the rate catalyzed by an enzyme is called the catalytic proficiency.

That old post [Enzyme Efficiency: The Best Enzyme] had a nice graphic showing the spontaneous rates of some reactions that take place quickly inside a cell.

Here it is ....

And here's how the information in that 2008 post got incorporated into the latest edition of my textbook.

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Better Biochemistry

This is a "Theme" post where I collect all previous posts on teaching biochemistry and molecular biology.

December 9, 2013
Monday's Molecule #226

December 6, 2013
Die, selfish gene, die!

December 6, 2013
Do you understand this Nature paper on transcription factor binding in different mouse strains?

December 2, 2013
Monday's Molecule #225

November 12, 2013
David Evans Says, "Teach What the Vast Majority of Scientists Affirm as Settled Science"

November 5, 2013
Stop Using the Term "Noncoding DNA:" It Doesn't Mean What You Think It Means

October 30, 2013
Time to Re-Write the Textbooks! Nature Publishes a New Version of the Citric Acid Cycle

October 29, 2013
The Khan Academy and AAMC Teach Evolution in Preparation for the MCAT

October 29, 2013
The Khan Academy and AAMC Teach the Central Dogma of Molecular Biology in Preparation for the MCAT

October 29, 2013
The Khan Academy and the Association of American Medical Colleges (AAMC) Team Up to Teach Evolution and Biochemistry for the New MCAT

October 24, 2013
ASBMB Core Concepts in Biochemistry and Molecular Biology: Matter and Energy Transformation

October 15, 2013
ASBMB Core Concepts in Biochemistry and Molecular Biology: Evolution

October 14, 2013
Fundamental Concepts in Biochemistry and Molecular Biology

October 11, 2013
ASBMB Promotes Concept Driven Teaching Strategies in Biochemistry and Molecular Biology

Another curious aspect of the theory of evolution is that everybody thinks he understands it. I mean philosophers, social scientists, and so on. While in fact very few people understand it, actually, as it stands, even as it stood when Darwin expressed it, and even less as we now may be able to understand it in biology. Jacques Monod (1974)October 8, 2013
On the Importance of Defining Evolution

October 6, 2013
Teaching Biochemistry from an Intelligent Design Creationist Perspective

October 1, 2013
The Many Definitions of Evolution

September 30. 2013
The Problems With The Selfish Gene

September 18, 2013
Breaking News!!! Wikipedia Is Wrong! (about the Central Dogma)

September 13, 2013
Sean Carroll: 'What Is Science?"

September 13, 2013
Better Biochemistry: Teaching ATP Hydrolysis for the MCAT

September 12, 2013
Better Biochemistry: Teaching to the MCAT?

June 27, 2013
The Best Enzyme

April 16, 2013
Where Do Organisms Get Their Energy?

April 10, 2013
Spontaneous Degradation of DNA

March 18, 2013
Estimating the Human Mutation Rate: Biochemical Method

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"Reasons to Believe" in ENCODE

Fazale "Fuz" Rana is a biochemist at Reasons to Believe". He and his colleagues are Christian apologists who try to make their faith compatible with science. Fuz was very excited about the ENCODE results when they were first published [One of the Most Significant Days in the History of Biochemistry]. That's because Christians of his ilk were very unhappy about junk DNA and the ENCODE Consortium showed that all of our genome is functional.¹

Fuz is aware of the fact that some people are skeptical about the ENCODE results. He wrote a series of posts defending ENCODE.

1. Do ENCODE Skeptics Protest Too Much? Part 1 (of 3)
2. Do ENCODE Skeptics Protest Too Much? Part 2 (of 3)
3. Do ENCODE Skeptics Protest Too Much? Part 3 (of 3)

The first post is merely a list of the objections many of us raised.

Read more »

Index of Speakers, Warsaw Congress 2013

206 Abbas Ali,  Hazem Hussein
43   Abd El-Maguid,  Mohamed
230 Abrams,  Alissa
40   Ahmed,  Eman
190 Ahmed,  Mohamed
140 Albarrán Martínez,  María Jesús
72   Alessandrelli,  Michele
212 Allam,  Schafik
17   Alonso,  Jose Luis
93   Aly,  Shereen  A.
123 Aly,  Magdy A.I.
260 Aly,  Eman
166 Ammirati,  Serena
82   Andorlini,  Isabella
104 Antoni,  Agathe
239 Arlt,  Carolin
46,168  Ast,  Rodney
23   Backhuys,  Thomas
196 Bafa,  Danai
1     Bagnall,  Roger s.
26   Balamoshev,  Constantinos
153 Balconi,  Carla
68   Ballesteros,  Blanca
102 Bartels,  Paul
54   Bartol,  Krystyna
20   Bay,  Stephen
219 Benaissa,  Amin
245 Berkes,  Lajos
48   Bernini,  Andrea
155 Blouin,  Katherine
137 Blumell,  Lincoln H,
224 Bonati,  Isabella
84   Bortolani,  Ljuba Merlina
95,171  Boud'hors,  Anne
133 Bowman,  Alan
37   Bravo,  Benedetto
142 Broux,  Yanne
251 Bryen,  Ari
204 Bsees,  Ursula
250 Buchanan,  Elizabeth
92   Bülow-Jacobsen,  Adam
246 Burchfield,  Richard
77,105  Capasso,  Mario
175 Capponi,  Livia
197 Carlig,  Nathan
55   Casanova,  Angelo
167 Castelli,  Emanuele
12   Cavallo,  Guglielmo
126 Chang,  Ruey-Lin
240 Chaufray,  Marie-Pierre
163 Choat,  Malcolm
257 Claytor,  W. Graham
41   Cohen,  Nahum
218 Colomo,  Daniela
128 Connor,  Andrew
199 Conti,  Eleonora
74   Corti,  Aurora
101 Cowey,  James M.S.
141 Criscuolo,  Lucia
172 Cromwell,  Jennifer
30, 60 Cuvigny,  Hélène
33   Dahlgren,  Sonja
14   Danielewicz,  Jerzy van
46   Davoli,  Paula
200 De  Francesca
143 De Frutos Garcia,  Alba
87   De Haro Sanchez,  Magali
147 De Jong,  Janneke H.M.
120 Del Mastro,  Gianluca
100,104 Delattre,  Alain
103 Depauw,  Mark
152 Deptuła,  Agata
109 Derda,  Tomasz
176 Deyab,  Yousry
170 Dijkstra,  Jitse H.F.
59   Dobbin-Bennett,  Tasha
247 Dolganov,  Anna
44   Dominguez Alberto,  Nodar
85   Dosoo,  Raymond Korshi
127 Dumke,  Gunnar
177 Dzierzbicka,  Dorota
42   El-Maghrabi,  MohamedGaber
El-Masry,  Seham
258 El-Sayed,  Fatma
180 Emanuele,  Enrico
116 Epstein,  Shimon
61, 212  Essler,  Holger
164 Falivene,  Maria Rosaria
21   Fernández-Delgado,  José-Antonio
88   Fimiani,  Mariacristina
90   Fiorillo,  Matilde
130 Fischer-Bovet,  Christelle
106 Fleischer,  Kilian
8, 131  Fournet,  Jean-Luc
166 Fressura,  Marco
112 Frösén,  Jaakko
242 Funderburk,  Kevin
98   Gad,  El-Sayed
229 Gad,  Usama
151 Gampel,  Alan
86   Gardner,  Iain
110 Garel,  Esther
95   Gascou,  Jean
191 Gaubert,  Christian
261 Gerardin,  François
102, 158  Gerhardt,  Marius
28   Godlewski,  Włodzimierz
254 Goñi,  Amaia
151 Grassien,  Celine
191 Gruber,  Christian-Jürgen
50   H.M.  Janneke
121 Hammerstaedt,  Jürgen
108 Hanafi,  Alia
221 Hanson,  Ann Ellis
111 Hartman,  Dorota
38   Haslam,  MichaelW.
207 Hassan Afandyn,  Abd el-Latif
203 Hatzilambrou,  Rosalia
129 Hauben,  Hans
195 Haug,  Brendan
36, 100  Heilporn,  Paul
119 Hendriks,  Sarah
213 Hengstl,  Joachim
220 Henry,  Benjamin W.
63   Hickey,  Todd
232 Hogan,  Andrew
236 Hoogendijk,  Francisca A.J.
83  Hussein,  Rasha
91   Indelli,  Giovanni
210 Jankowiak,  Marek
225 Jesenko,  Alexandra
70   Johnston,  Jay
4     Jördens,  Andrea
113 Kaimio,  Jorma
62   Keenan,  James
156 Kott,  Déborah
39   Kotyl,  Marcin
238 Kovarik,  Sophie
193 Kruse,  Thomas
234 Kugler,  Rob
185 Kwapisz,  Jan
145 Landvatter,  Thomas
76   Langellotti,  Micaela
50   Legendre,  Marie
243 Lemaire,  Florence
73   Leone,  Giuliana
211 Lev,  Yaacov
168 Lifshits,  Alexander
3    Lippert,  Sandra
91   Longo,  Francesca
217 López Martínez,  María Paz
168 Lougovaya,  Julia
134 Luijendijk,  AnneMarie
159 Łukaszewicz,  Adam
125 Lundon,  John
183 Macedo,  Gabriel Nocchi
149 Macfarlane,  Roger T.
114 Mairs,  Rachel
188 Malczycki,  Matt W.
80   Malouta,  Myrto
165 Maltomini,  Francesca
255 Maravela,  Anastasia
162 Marganne,  Marie-Hélène
178 Maria,  Anna
244 Marthot,  Isabelle
64   Martin  Alain
66   Martín-Hernánde,z  Raquel
47   Martín,  Elena
57   Martinez,  David
181 Martis,  Chiara
53   McNamee,  Kathleen
107 McOsker,  Michael
52   Meccariello,  Chiara
264 Meerson,  Michael
16   Mélèze,  Joseph
29   Menci,  Giovanna
124  Miller,  Martin
13   Minnen,  Peter van
161 Mirkovic,  Miroslava
19   Mirończuk,  Andrzej
104 Monet,  Annick
25   Monson,  Andrew
102 Monte,  Anna
223 Monte,  Anna
51   Montemurro,  Fjodor
9     Morelli,  Federico
132 Mossakowska-Gaubert,  Maria
157 Naether,  Franziska
214 Nasti,  Fara
248 Nowak,  Maria
209 Nowakowski,  Paweł
15   Obbink,  Dirk
148 Ochała,  Grzegorz
201 Otranto,  Rosa
144 Paganini,  Mario C.D.
237 Pajón Leyra,  Irene
6     Palme,  Bernhard
118 Parisi,  Antonio
231 Pedro,  Rodolfo
216 Pellé,  Natascia
154, 186 Perale,  Marco
182 Płóciennik,  Tomasz
179 Pordomingo,  Francisca
238 Prada,  Luigi
78   Quenouille,  Nadine
89  Ranocchia,  Graziano
5     Rathbone,  Dominic
116 Reggiani,  Nicola
11   Reinfandt,  Lucian
102 Reiter,  Fabian
208 Remijsen,  Sofie
160 Renner,  Timothy
241 Resel,  Markus
222 Ricciardetto,  Antonio
252 Rodriguez,  Chris
94   Rodríguez,  Amalia Zomeño
27   Römer,  Cornelia
81   Rossi,  Lucia
122 Rufilanchas,  Daniel Riaño
217 Ruiz Montero,  Consuelo
131 Russo,  Simona
138 Salem,  Noha A.
Salem,  Noha A.
202 Salemenou,  Maroula
75   Salmenkivi,  Erja
35   Sampson,  Michael C.
233 Sánchez-Moreno,  Carlos
34   Sänger,  Patrick
22   Santamaría,  Marco Antonio
58   Sarischouli,  Panagiota
198 Sarri,  Antonia
31   Scappaticcio,  Maria Chiara
173 Schenke,  Gesa
24   Scheuble-Reiter,  Sandra
135 Schironi,  Francesca
187 Schubert,  Paul
18   Sebastian,  Tonio
262 Skalec,  Aneta
146 Smith,  Gavin
99   Soliman,  Suzanne
194 Stankovic,  Emilija
227 Stern,  Matthias
32   Stolk,  Joanne
150 Stroppa,  Marco
49   Szántó,  Zsuzsanna
184 Tezzon,  Valeria
169 Theis,  Christoffer
189 Thomann,  Johannes
2     Thompson,  Dorothy J.
97   Tirel,  Claudia
94   Torallas,  Sofía
226 Tost,  Sven
96   Trnka-Amrhein,  Yvona
174 Tsakos,  Alexandros
235 Ucciardello,  Giuseppe
215 Urbanik,  Jakub
142 Vanbeselaere,  Silke
139 Vanderheyden,  Loreleï
65, 205  Vanthieghem,  Naïm
71   Vassallo,  Christian
253 Vega,  Natalia
259 Verhoogt,  Arthur
115 Verreth,  Herbert
117 Vierros,  Marja
10   Vliet,  Jacques van der
249 Waebens,  Sofie
256 Walter,  Vincent
136 Wayment,  Thomas
69  Willer,  Laura
7     Wipszycka,  Ewa
263 Wojtczak,  Marzena
146 Yiftach-Firanko,  Uri
67   Yuen-Collingridge,  Rachel

One of the Most Significant Days in the History of Biochemistry

Reasons to Believe is "where science and faith converge." It's the organization founded by creationist Hugh Ross, a graduate of the University of Toronto. One of his leading minions is Fazale ("Fuz") Rana, a biochemist.

Fuz says that "September 5, 2012 marks one of the most significant days in the history of biochemistry."

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Marc Kirschner Defends Basic Science

Marc Kirschner is Chair of the Department of Systems Biology at Harvard Medical School. He's a very smart man and a well-respected scientist.¹ He has an editorial in the June 14th issue of Science: A Perverted View of “Impact” [see also: In search of big breakthroughs: why attempts to predict ‘significant’ research might backfire in The Boston Globe]

Kirschner says that the emphasis on "significance" and "impact" in making funding decisions is "misleading and dangerous." Nobody can really predict how fundamental research will affect the future. He writes ...
Read more »

Greg Crane on Digital Humanities and open source publication

Monday's Molecule #206

Last week's molecule was myricyl palmitate, the major component of beeswax [Monday's Molecule #205]. The winner was Bill Chaney. There was no undergraduate winner.

Today's molecule is a very common molecule shown in a somewhat unusual conformation. (It's the conformation of the molecule when it's bound to a certain enzyme.) Identify the molecule (common name only). Can you describe the conformation?

Email your answers to me at: Monday's Molecule #206. I'll hold off posting your answers for 24 hours. The first one with the correct answer wins. I will only post mostly correct answers to avoid embarrassment. The winner will be treated to a free lunch.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your email message.)

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Laurence Hurst Discusses Junk DNA

Laurence Hurst is a Professor of Evolutionary Genetics in the Department of Biology and Biochemistry at The University of Bath (United Kingdom). He did his graduate studies under W.D. Hamilton at Oxford so it's safe to assume that he has adaptationist leanings.

Hurst wrote a comment in BMC Biology where he criticized the logic employed by those of us involved in the junk DNA debate [Open questions: A logic (or lack thereof) of genome organization]. Here's part of what Hurst says about logic ...

As a graduate student I was advised that if you don’t understand why an animal does what at first sight looks like behavior contrary to its best interests, then you should presume that it is you, not the animal, that is stupid. Look harder, the wisdom goes, and you will discover natural selection’s cunning logic.

That's bad advice, as Stephen Jay Gould and Richard Lewontin pointed out 35 years ago [The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme]. But, like many adaptationists, Hurst is willing to concede that this kind of reasoning may not apply at the molecular level.

While this may be good advice to those studying organismic behavior or anatomy, when we approach genomic anatomy and behavior it will not do.

Indeed, typically when thinking about genomes people often make the opposite presumption. Intergenic DNA was dismissed as irrelevant junk and many transcripts are presumed to be just so much noise. Synonymous mutations have been assumed to be neutrally evolving and where in a genome a gene sits is considered to be largely irrelevant. But are these assumptions more witness to a lack of understanding rather than robust statements about how genomes function and evolve? You are, after all, alive reading this, testament to the fact that your genome is doing something right.

So then, what features of our and other genomes are functionally relevant and which just so much noise? More importantly, when selection does act, why is it acting?

Hurst seems to be assuming that we know nothing about most of the genome and he makes the erroneous assumption that junk DNA advocates dismiss all intergenic DNA as junk. These are the hallmarks of someone who is uniformed about the debate over junk DNA. There is strong positive evidence for junk and those arguments need to be addressed (e.g. genetic load, C-Value Paradox). There is also strong evidence for functional intergenic sequences (origins, centromeres. telomeres, SARs, regulatory regions, etc.) and that evidence is part of the debate. None of the advocates of junk DNA claim that all intergenic DNA is junk.

We know that half of our genome is composed of bits and pieces of defective transposons. That's not ignorance. Broken genes are ... broken genes. They don't work. They are junk. We know enough about genes to recognize the difference between active functional transposons and those that carry lethal mutations of are missing large pieces of their coding region. It's logical to conclude that about half of our genome is junk based on those facts alone.

We know enough about transcription to know that spurious transcription and production of junk RNA transcripts are an inevitable consequence of the basic biochemistry of DNA binding proteins. That's not ignorance.

We know enough about nearly neutral mutations and molecular evolution to know the the existence of an approximate molecular clock means that most synonymous mutations and amino acid substitutions are fixed by random genetic drift. That's not due to a lack of understanding. Hurst has published evidence that some of these seemingly neutral mutations affect function but he ignores the evidence that most behave as if they were neutral.

The fact that you are alive does, indeed, mean that your genome is doing something right. It's good enough for survival of our species. It does not mean that all of your genome is functional.

To his credit, Hurst recognizes that the ENCODE scientists were wrong and that the null hypothesis is NOT natural selection.

The challenge is difficult. Assuming that sites involved in interactions are all functional isn’t good enough. By this, the logic employed by ENCODE, following a collision between a car and a pedestrian, a car’s bonnet would be ascribed the 'function' of projecting a pedestrian many meters and the pedestrian would have the 'function' of deforming the car’s bonnet. Similarly, we expect, for example, accidental transcription factor-DNA binding to go on at some rate, so assuming that transcription equals function is not good enough. The null hypothesis after all is that most transcription is spurious and alternative transcripts are a consequence of error-prone splicing. Conversely, assuming unbound sequence, such as nucleosome-free regions, to be lacking in function can mislead, as they can be critical for the proper control of gene expression.

I get the feeling that Hurst is uncomfortable with the idea that most of our genome is junk [see Hacking the Genome] but he's at least on the right track when he recognizes that there's still a legitimate scientific debate.

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Hat Tip: Dan Graur: Laurence Hurst’s Error: The Inability to Distinguish between a Stupid Animal, a Dead Animal, and the Elephant in the Room

Are You an Evolutionist?

Dan Graur has written a post on The Evolution of "Evolutionist". He points out that the term "evolutionist" and "evolutionism" used to refer to those who accept the fact of evolution and support evolutionary theory.

However, he also notes that ...

Since 2000, it is impossible to find the terms “"evolutionist" and "evolutionism" used by anyone except by creation apologists.... I would greatly like to know when exactly was the evolution of "evolutionist" completed and the term acquired its present negative connotation.

I prefer the term "evolutionary biologist" to describe scientists who are experts on evolution. For those non-experts who accept the basic principles of biology, chemistry, physics, geology etc. we don't need a term other than "rational." It's silly to describe them as "gravitationists" or "plate tectonicists" or "thermodynamicists."

Do you ever refer to yourself as an evolutionist?

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Subject Index to the Program of the Warsaw Congress (correctior)

Abinnaeus Archive 78
Acta Alexandrinorum 251
Acta Appiani 252, 253
Administration 4, 6
Administration, village 245
Ain Shams 207
Alexandria 43
Amheida (Dakhla) 46
Amulets 69, 70, 87
Anacreon 38
Anacreontea 37
Anoubion 187
Antinoopolis 80, 183
Apa Isaiah 150
Apa Sabinios 140
Aphrodite 95*, 243, 244
Apostle Paul 213
Arab Egypt 190, 204, 210
Arab names 50, 147
Arabic papyri 9, 11, 65, 99, 173, 188, 206, 207, 189,  191,
Arabic Papyri in the Egyptian Library. 204
Arabic papyrology 9, 11
Aramaic documents 114
arcaheology 29, 43, 44, 132, 145
Archaic / Hellenistic Greece 14
archival pratices 144
Archive, bilingual 95
Archive, Coptic 140
Aristarchus 2.0 (info.tech.) 122
Army, Ptol. 130
Army, Roman 178
Army, Roman 177
Arsinoite nome 238
Arsinoites polis 146
Asceticism 150
Asian Saints 209
astronomical poem 154
Augustus, reign of 175
authenticating documents 202
Babatha Archive 111, 261
Bactria 114
Bakchias 241
basilica, construction 109
Berenike 160
Berliner Papyrusdatenbank (info.tech.) 102
BGU VIII 1844 262
Bibliothèque Nationale de France 155
big data 103
bilingual glossaries 166
bilingual interference 33
bilingual: Greek-Demotic 232
Bingen, Jean 205
Bodleian Disegni (19the century drawings of lost frags.) 119
book collections 164
boule papyri (Karanis) 258
Briefe (letters) 61
burial 250
Byzantine documents, 95*
Byzantine Egypt 243, 244, 8, 125, 123, 149, 229, 139
Calpurnius Proculus, C. 175
changes in handwriting 198
Christian letters, recommendation 255
Christian papyri 137
Christian symbols & abbreviations 197
Christianity 7, 152, 167,  210, 213, 168, 209, 208
Christianity & Magic 169
chronciles, Alexandrian world 170
circumcision 98
classical sources 16
Cleopatra papyrus 158
codex Tischendorfianus I  = Uncial 0106 N-A 28 168
commentary, Anacreon 38
commentary, Eur. Phoen. 53
conservation 207
contract: lease 41
contract: sublease of land 42
contracts 76, 123
Coptic biblical texts 169
Coptic documents 10, 11, 18, 95, 171, 172
correction & expunction, typology 181
court proceedings 233
cultural history 8
curriculum vitae of St Paul 213
dative replaced by genitive case 32
DCLP (Digital Corpus of Literary Papyri, info.tech.) 121
de legatis et fideicommissis 214
debates in the Acta Appiani 252
debt & land (priest in Roman Egypt) 242
declamation, handbook 218
Demetrius Laco 118
Demetrius Laco, On Poems 107
Demosthenes, de Corona 202
Demosthenes, Philippic 3 200
Demotic texts 3, 156, 157
Deuteronomy, LXX 134
diachrony, linguistic change over time (case use) 32
Didascalia CCCXVIII Patrum Nicaenorum 137
Dimē (SokNes), temple accounts of 240
dispute resolution, Byz. 263
divination 236, 238
Djeme 97, 245
documentary papyri (oneirocriticon) 23, 24, 25, 26, 41, 42, 58, 108, 204
donkey, hiring 212
doxology 137
drawing: biblical  scene 60
dream interpretation 238
early Egypt 146
Eastern desert 60
Edfu 156
education, rhetorical 218
Egyptian Museum 138
Egyptian religion 84, 240
Egyptian religion, Priests 242
Egyptian scribe 33
eklogistes (ἐκλογιστής) 191
elegy, astrology 187
Elephantine 93
emphyteusis (ἑμφύτευσις) 215
enforcement agency (Erwinungsstab) 226
entagion (ἐντάγιον) Order for delivery 125
Epicurus 73, 74
epigrams 14
epistolography, Christian 255
epistolography, Coptic 256
epistolography, women 254
Euripides, Alexandros 235
Euripides, Melanippe Desmotis 51
Euripides, Phoeissae 53
Euripides, Phoeissae 51, 52
Eusebian Canons 136
exegesis of Demosthenes 201
family history 1
Fatamid period 191
Fayyum: Philoteris 27 ,195
Galerius, Emperor 194
geography 27
Gerontius Archive 78
Goodspeed, E.J. 62, 63
Gospel titles 167
grammar 31
granary C123, Karanis 259
grapheion, Arsinoite 146
Great Persecution 7
Greco-Egyptian law 17
Greek & Latin, bilingual interference 162
Greek documents 9 , 114
Greek Language 117
Greek lyric 36
Greek mss., Nubia 174
Greek papyri 95, 99, 147
Greek papyrus collection 155
Greek, medical papyri and 221
Handbook of Ritual Power 86
Hawara Homer 19
Hecrulaneum papyri 71, 72, 73, 74, 77, 88, 89, 90, 91, 104, 106, 107, 118, 119, 120
Hellenistic, literary papyri, 154
herbs 68
Hesiod 21, 22
heterogeneity, legal 230
hierarchies of slave, Imp.Rom. 160
Hieratic - Demotic texts 239
Hipparchic system 24
history 2, 3,
history of Papyrology 61, 62, 63, 64, 205
Homer 19, 20
horoscope 189
hymnography 84, 152
hypotheses of orators 203
hypotheses, Eurip., Orators 52, 203
identifiers, inof.tech. 103
illegitimate children, heredity, legal 248, 249
image & text 70
imprisonment 227
in flexion of verbs 31
information technology (info.tech, or IT) 100, 101, 103, 115, 116, 117, 121, 122, 133
inheritance 249
Inscribed objects 29
irrigation 244
Islamic period / Arab Egypt 190, 204, 210
Islamic period, early — Byzantine period, late 211
jails 227
Jews 49
Judea 234
Juvenal 183
Karanis 145
Karanis, Roman 133, 257, 258, 259
Karanis, topography 260
Katbasis of Theseus & Perithoös 22
Kellis 236
land boundaries, disputed 57
land management 128
Large Oasis 153
Late Antiquity
Late Antiquity 1, 6, 18, 28, 140, 150, 170, 195, 196, 226, 208, 225, 238, 245, 246
Late Byzantine / early Islamic period 211
Later Roman Egypt 78
Latin 221, 162
Latin palaeography 183
Latin texts 182
Law 232, 233, 264, 263
Law, Ptolemaic, 230, 234
Law, Roman 219, 247, 214, 261, 215, 248, 249
lectional signs 66
legal history 16, 17, 18
Leipzig 157
letter in a bookhand 199
letters 139, 224
Lexicon 55
linguistic analysis 122
Linguistics 32
linguistics 31
literacy 146
literary and documentary texts, connections 162
literary papyri (papirologia letteraria) 12, 13, 19, 20, 21, 22, 35, 36, 37, 38, 47, 51, 52, 53, 54, 58, 121, 151, 154 ,179, 180, 181, 183, 184, 185, 186, 187, 200, 201, 216, 217, 220, 235, 251, 252, 253
literary papyri, hypotheses 52
literary papyri, Sappho 35
literary papyri: not 58
loans & deposits 247
LXX 134
lyric poetry 14, 35, 36, 47, 180
magic papyri 47, 66, 67, 68
magical forumlae 66, 67, 68, 69, 70, 84, 85, 86, 87
magical handbooks 85
Marea 109
marriage, Dowry 247
material culture 131
medical 221, 222, 223
medical poets 220
Medicine chest? 224
Memnon 96
Menander, Epitrepontes 801=835 55
methodology 46
metre 185
metrical markers 180
Middle Comedy 54
Minnesota, Papyrus collections 186
minors, law 264
monastery al Naqlun, fayyum 191
monastery of al Wizz 174
monastery of Ghazeli 148
monastery of Nekloni 28
monastery of Saint Aaron 112
monateries and context 246
Mons Claudianus 176
mother, guardianship 264
multilingualism 148
navy, Ptol. 225, 130
new discoveries 105
new texts 75
Nile 81
NT 34
NT Uncial 0106 (N-A 28) 168
Nubia, Christian 148, 152, 174
Numeri Dacorum 178
numerology 126
O.Minnesta 1-2 186
official bureaucracy 191, 193
On Nature 25 74
On Nature, 2 73
oneirocriticon (dream interpretation) 238
onomastics 49, 50
oracle 236
Origen 135
ostraca 46, 92, 93, 94, 105, 109, 110, 138
ostraca, inedit. 93, 94, 138
Oxyrhynchus 154, 229
P. Berol. 13270 = LDAB 6927 184
P. Berol. 7927 + 9588 + 21179 217
P. Bingen 45 158
P. BM 10591 Vo i-iv 232
P. Brem. 5 159
P. Duk. F 1984.7 = Fr. 1146 K.-A 54
P. Duke Inv. 766 151
P. Dura 31 261
P. Fay. 221 40
P. Grenf. I 5 135
P. Haun 214
P. Heid. Inv. G 310a 185
P. Herc. 1021 col. XXXIII-XXXV 106
P. Herc. 124 118
P. Herc. 188 107
P. Herc. Paris. 2 104
P. Lit. Lond. 179 201
P. Mich. Inv. 918 e 200
P. Mich. XIII 659 263
P. Minnesota 1-22 186
P. Oxy. LXIV 4405 136
P. Oxy. VI 905   261
P. Oxy. XLVIII 3372 38
P. Oxy. XXII 2321 fr. 1 ll. 1-12 37
P. Oxy. XXXI 2607 238
P. Petra 17 113
P. Polit. Iud. 3-5: 234
P. Ryl. III 458 134
P. Utah. Ar. Inv. 280: 188
P. Vind. Inv. A. Perg. 236 189
P.Dura 31 261
P.Oslo 2.54 224
P.Würzburg 1 53
Pagarch 227
palaeography 12, 44, 182, 198, 199
palimpsests 149
Pamphilius 55
papyri.info (info.tech.) 101
papyrology 145
papyrus rolls 165
Parthenope Romance 217
Paschal letters 210
Patristics 135, 136
Penthemeros certificates 40
petition 57
Petra 112, 113
PGM IV 2211 47
PGM IV and VII 67
PGM VII 66
PGM XIII 68
pharmacological recipe 223
pharmacology 222
Pharonic Egypt 212
Philodemus 88
Philodemus, "La libertà di parola" 91
Philodemus, Index Academicorum 106
Philodemus, On Calumny 104
Philodemus, On Praise (de adulatione) 77
Philodemus, On Rhetoric bk 7, 89, 90
physical force, policing 231
places, Oxyrhynchus 124, 44
poem, Abu Dulaf al-'Ijl 188
poetic canon 151
poetic texts 179
police 226
Polish papyrus Collections 156
politeuma (πολίτευμα) 34
prayers for the dead 250
Presocratic quotations 71
property, division 113
prosangelma 26
prose literary papyri 15
prosopography 229
psal(l)idion 48
Psenharpsenêsis 260
Ptolemaic - Roman Egypt 116, 144
Ptolemaic Egypt
Ptolemaic Egypt 2, 16, 24, 25, 26, 49, 50, 57, 75, 127, 129, 128, 130, 143, 142, 158,  164, 230, 231, 262,
Ptolemy I Soter 127
Qasr Ibrim 182
Rashid ibn Chaled 173
re-use of papyrus 28, 165
re-used roll 216
receipt 59
retrospective, literary texts 13
retrospective, palaeography 12
retrospective, prose 15
Rhetoric bk. 4, Philodemus 88
river Merchants 81
river transport 129
roll reconstruction 89, 120
Roman Egypt 4, 5, 17, 19, 59, 60, 69, 76, 80, 82, 92, 98, 163, 177, 193, 194, 242, 254,
Roman Egypt (Diocletian) 7, 40
Roman Egypt, Official correspondence 159
Roman Egypt, Slavery 160
Roman Palestine 111
Roman-Arab Egypt 99
Romanitas 5
Royal / Temple land 128
royal oath 23
rumors 253
salutations, dual 159
Sammlung der papyrus Erzherzog Rainer, Wien 190
Sappho: 44 35
scholia, Iliad 20
scribal practice 163
scribes 111
scriptio plena : elision 179
Sesostris 96
Seth 86
Sheikh Abd el-Gurna hermitage TT 1152 110
social history 6
Social network analysis 142
Soknopaiou Nesos 239
stenography 175
stichometry 163
stipulations before 212 AD 261
Stoic writer, anonymous 72
Strasbourg 65
sub-literary papyri 20
Sunday 208
Syene 94
sympotica 184
Synopsis project (info.tech.) 116
taxation 161
taxation: harvest 25
Taxation: tax Rolls, Karanis 133
Tebtunis 62, 75
temple documents 239, 241
Temple of Soknobkonneus 241
Temple of Soknopaiou 240
term-length, (admin. office) 191
testament (will), duplicate 172
Thebes 246
threshhold Archive, Karanis 257
Thucydides 216
titles 180
topography 27, 115, 195
topoteretai (admirals) τοποτηρηταί 225
trade 81
travel documents (Laissez-passers) 176
trends 85
trier collection 233
Tura find 149
typology 166
typology 87
Università Cattolica di Milano 153
used in pagan texts 197
vestis militaris 59
Victor the Priest 110
voluntary associations 143
Wessely 64
Wheat trade, Fustat 190
Wilcken 61
will, carbonized papyrus 112
wine request 124
wine supply 177
word studies 34, 47, 48, 131
writing practice 219
Xeron Pelagos (Feisaleya) 92
Zenon Archive 129,142
Zombies? 237

DM Heinz Heinen, 1941-2013

Heinz Heinen - Lebenslauf

1
Kindersklaven – Sklavenkinder
Stuttgart : Steiner, 2012

2
Antike Sklaverei - Rückblick und Ausblick
Stuttgart : Steiner, 2010, 1. Aufl.

3
Kleopatra-Studien
Heinen, Heinz. - Konstanz : UVK, Univ.-Verl. Konstanz, 2009

4
Festschrift für Heinz Heinen
Trier : Rheinisches Landesmuseum, 2008

5
Menschenraub, Menschenhandel und Sklaverei in antiker und moderner Perspektive
Stuttgart : Steiner, 2008

6
Geschichte des Hellenismus
Heinen, Heinz. - München : Beck, 2007, Orig.-Ausg., 2., durchges. Aufl.

7
Historia del helenismo
Heinen, Heinz. - Madrid : Alianza Ed., 2007

8
Antike am Rande der Steppe
Heinen, Heinz. - Stuttgart : Steiner, 2006

9
Vom hellenistischen Osten zum römischen Westen
Heinen, Heinz. - Stuttgart : Steiner, 2006

10
Geschichte des Bistums Trier / Bd. 1. Im Umbruch der Kulturen
2003, 1. Aufl.

12
Pontische Studien
Vinogradov, Jurij Germanovič. - Mainz : von Zabern, 1997

13
Frühchristliches Trier
Heinen, Heinz. - Trier : Paulinus, 1996, 1. Aufl.

14-15-16
Trier und das Trevererland in römischer Zeit
Heinen, Heinz. - Trier : Spee-Verl., 1993, 2., leicht überarb. und um einen bibliogr. Nachtr. erw. Nachdr., 3., unveränd. Nachdr.  

17
Althistorische Studien
Wiesbaden : Steiner, 1983

18
Die Anfänge des römischen Trier
Heinen, Heinz. - Trier : Verkehrsamt, 1983

19
Syrische Grabreliefs hellenistischer und römischer Zeit
Parlasca, Klaus. - Mainz am Rhein : von Zabern, [1983]

20
Die Geschichte des Altertums im Spiegel der sowjetischen Forschung
Darmstadt : Wissenschaftliche Buchgesellschaft, [Abt. Verl.], 1980

21
Untersuchungen zur hellenistischen Geschichte des 3. [dritten] Jahrhunderts v[or] Chr[istus]
Heinen, Heinz. - Wiesbaden : Steiner, 1972

22
Rom und Ägypten von 51 bis 47 v. Chr. Untersuchgn zur Regierungszeit d. 7. Kleopatra u. d. 13. Ptolemäers
Heinen, Heinz. - Tübingen, 1967

23
Handwörterbuch der antiken Sklaverei [Elektronische Ressource]
Stuttgart : Steiner