"Impossible" Molecular Machines

Someone named vjtorley just posted a list of things that would falsify his faith in Intelligent Design Creationism [The 10^(-120) challenge, or: The fairies at the bottom of the garden].

Normally this wouldn't be very interesting because the IDiots almost always set up impossible criteria reflecting their fundamental misunderstanding of evolution. This posting is no exception but I was intrigued by one of the items on the list.

2. An empirical or mathematical demonstration that the probability of the emergence of any of the irreducibly complex structures listed on this page, as a result of non-foresighted processes (“random mutations plus natural selection”) is greater than 10^(-120).

The link under "this page" is to an article by Casey Luskin from last June [Molecular Machines in the Cell]. He lists a whole bunch of molecular machines and claims that these structures pose a real problem for science.

Here's the list. Judge for yourselves whether they make you believe in God.

Molecular machines are highly complex and in many cases we are just beginning to understand their inner workings. As a result, while we know that many complex molecular machines exist, to date only a few have been studied sufficiently by biologists so that they have directly tested for irreducible complexity through genetic knockout experiments or mutational sensitivity tests. What follows is a non-exhaustive list briefly describing 40 molecular machines identified in the scientific literature. The first section will cover molecular machines that scientists have argued show irreducible complexity. The second section will discuss molecular machines that may be irreducibly complex, but have not been studied in enough detail yet by biochemists to make a conclusive argument.


I Molecular Machines that Scientists Have Argued Show Irreducible Complexity

1. Bacterial Flagellum
2. Eukaryotic Cilium
3. Aminoacyl-tRNA Synthetases (aaRS)
4. Blood clotting cascade
5. Ribosome
6. Antibodies and the Adaptive Immune System

II. Additional Molecular Machines

7. Spliceosome
8. F0F1 ATP Synthase
9. Bacteriorhdopsin
10. Myosin
11. Kinesin Motor
12. Tim/Tom Systems
13. Calcium Pump
14. Cytochrome C Oxidase
15. Proteosome
16. Cohesin
17. Condensin
18. ClpX
19. Immunological Synapse
20. Glideosome
21. Kex2
22. Hsp70
23. Hsp60
24. Protein Kinase C
25. SecYEG PreProtein Translocation Channel
26. Hemoglobin
27. T4 DNA Packaging Motor
28. Smc5/Smc6
29. Cytplasmic Dynein
30. Mitotic Spindle Machine
31. DNA Polymerase
32. RNA Polymerase
33. Kinetochore
34. MRX Complex
35. Apoptosome / Caspase
36. Type III Secretory System
37. Type II Secretion Apparatus
38. Helicase/Topoisomerase Machine
39. RNA degradasome
40. Photosynthetic system

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